InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hdac10

Summary

InnateDB Protein

IDBP-172489.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hdac10

Protein Name

histone deacetylase 10

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000080832

InnateDB Gene

IDBG-172487 (Hdac10)

Protein Structure

UniProt Annotation

Function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Excluded from the nucleoli. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004407	histone deacetylase activity
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0033558	protein deacetylase activity
GO:0042826	histone deacetylase binding
GO:0046969	NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0046970	NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0097372	NAD-dependent histone deacetylase activity (H3-K18 specific)

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006476	protein deacetylation
GO:0014003	oligodendrocyte development
GO:0016575	histone deacetylation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0070932	histone H3 deacetylation
GO:0070933	histone H4 deacetylation