InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Hdac10

Summary

InnateDB Gene

IDBG-172487.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hdac10

Gene Name

histone deacetylase 10

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000062906

Encoded Proteins

IDBP-172489

histone deacetylase 10

IDBP-262578

histone deacetylase 10

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100429:
The protein encoded by this gene belongs to the histone deacetylase family, members of which deacetylate lysine residues on the N-terminal part of the core histones. Histone deacetylation modulates chromatin structure, and plays an important role in transcriptional regulation, cell cycle progression, and developmental events. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:89123307-89128700

Strand

Reverse strand

Band

Transcripts

ENSMUST00000082197	ENSMUSP00000080832
ENSMUST00000109347	ENSMUSP00000104971
ENSMUST00000129398
ENSMUST00000143465
ENSMUST00000128908
ENSMUST00000134111
ENSMUST00000138245
ENSMUST00000153195

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004407	histone deacetylase activity
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0033558	protein deacetylase activity
GO:0042826	histone deacetylase binding
GO:0046969	NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0046970	NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0097372	NAD-dependent histone deacetylase activity (H3-K18 specific)

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006476	protein deacetylation
GO:0014003	oligodendrocyte development
GO:0016575	histone deacetylation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0070932	histone H3 deacetylation
GO:0070933	histone H4 deacetylation