Version 5.4
Homo sapiens Protein: CHGA
Summary
InnateDB Protein IDBP-17252.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CHGA
Protein Name chromogranin A (parathyroid secretory protein 1)
Synonyms CGA;
Species Homo sapiens
Ensembl Protein ENSP00000216492
InnateDB Gene IDBG-17248 (CHGA)
Protein Structure
UniProt Annotation
Function Pancreastatin strongly inhibits glucose induced insulin release from the pancreas.
Subcellular Localization Cytoplasmic vesicle, secretory vesicle lumen {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250}. Secreted. Note=Associated with the secretory granule membrane through direct interaction to SCG3 that in turn binds to cholesterol-enriched lipid rafts in intragranular conditions. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0008217 regulation of blood pressure
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005576 extracellular region
GO:0030141 secretory granule
GO:0030658 transport vesicle membrane
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR001819 Chromogranin A/B
IPR001990 Chromogranin/secretogranin
PFAM PF01271
PRINTS PR00659
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P10645
PhosphoSite PhosphoSite-P10645
TrEMBL
UniProt Splice Variant
Entrez Gene 1113
UniGene Hs.150793
RefSeq NP_001266
HUGO HGNC:1929
OMIM 118910
CCDS CCDS9906
HPRD 07170
IMGT
EMBL AK223381 AK313757 AL117192 BC001059 BC006459 BC009384 BC012755 BT006869 CH471061 J03483 J03915 U03742 U03743 U03744 U03745 U03746 U03747 U03748 U03749
GenPept AAA52017 AAA52018 AAB53685 AAH01059 AAH06459 AAH09384 AAH12755 AAP35515 BAD97101 BAG36496 EAW81505

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca