Version 5.4
Homo sapiens Gene: CHGA
Summary
InnateDB Gene IDBG-17248.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CHGA
Gene Name chromogranin A (parathyroid secretory protein 1)
Synonyms CGA
Species Homo sapiens
Ensembl Gene ENSG00000100604
Encoded Proteins
IDBP-17250
chromogranin A (parathyroid secretory protein 1)
IDBP-17252
chromogranin A (parathyroid secretory protein 1)
IDBP-590914
chromogranin A (parathyroid secretory protein 1)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21214543
CHGA undergoes proteolytic cleavage to give rise to biologically active peptides, including catestatin. Catestatin is a neuroendocrine peptide with effects on human autonomic function and has recently been found to be a cutaneous antimicrobial peptide by inducing mast cell activation. In mast cells, catestatin plays a role in the migration, degranulation and release of leukotriene and prostaglandins; in addition, catestatin also induces production of pro-inflammatory cytokines to prime the innate immune response.
InnateDB Annotation from Orthologs
Summary
PMID 21214543
[Mus musculus] Chga undergoes proteolytic cleavage to give rise to biologically active peptides, including catestatin. Catestatin is a neuroendocrine peptide with effects on human autonomic function and has recently been found to be a cutaneous antimicrobial peptide by inducing mast cell activation. In mast cells, catestatin plays a role in the migration, degranulation and release of leukotriene and prostaglandins; in addition, catestatin also induces production of pro-inflammatory cytokines to prime the innate immune response.
Entrez Gene
Summary The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Other peptides, including chromostatin, beta-granin, WE-14 and GE-25, are also derived from the full-length protein. However, biological activities for these molecules have not been shown. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Two other peptides, catestatin and chromofungin, have antimicrobial activity and antifungal activity, respectively. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:92923080-92935293
Strand Forward strand
Band q32.12
Transcripts
ENST00000334654 ENSP00000334023
ENST00000216492 ENSP00000216492
ENST00000556076 ENSP00000450801
ENST00000553866
ENST00000556098
ENST00000556876
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0008217 regulation of blood pressure
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005576 extracellular region
GO:0030141 secretory granule
GO:0030658 transport vesicle membrane
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021194
View Gene Order
ENSBTAG00000009836
Not yet available
Cross-References
SwissProt P10645
TrEMBL G3V2Q7 G5E968 Q86T07
UniProt Splice Variant
Entrez Gene 1113
UniGene Hs.150793
RefSeq NM_001275 XM_005267292 XM_006725160
HUGO HGNC:1929
OMIM 118910
CCDS CCDS9906
HPRD
IMGT
EMBL AK223381 AK313757 AL117192 BC001059 BC006459 BC009384 BC012755 BT006869 BX248263 CH471061 J03483 J03915 U03742 U03743 U03744 U03745 U03746 U03747 U03748 U03749
GenPept AAA52017 AAA52018 AAB53685 AAH01059 AAH06459 AAH09384 AAH12755 AAP35515 BAD97101 BAG36496 CAD62591 EAW81505 EAW81506
RNA Seq Atlas 1113

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca