InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cd97

Summary

InnateDB Protein

IDBP-172604.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cd97

Protein Name

CD97 antigen

Synonyms

AA409984; TM7LN1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000002964

InnateDB Gene

IDBG-172600 (Cd97)

Protein Structure

UniProt Annotation

Function

Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. Plays an essential role in leukocyte migration. {ECO:0000269PubMed:14707087}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:10540231}; Multi-pass membrane protein {ECO:0000269PubMed:10540231}.

Disease Associations

Tissue Specificity

Although predominantly expressed by cells of the immune system is expressed ubiquitously, with particularly high levels of expression in the lung and the thymus gland. In the spleen, expression is detected on most myeloid cells and variable portions of T-cells, B-cells and NK cells. In the bone marrow, expressed in nearly all myeloid cells, whereas little if any expression is found on erythroid cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0007155	cell adhesion
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007218	neuropeptide signaling pathway
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1347095

InterPro

IPR000203 GPS motif
IPR000742 Epidermal growth factor-like domain
IPR000832 GPCR, family 2, secretin-like
IPR001740 GPCR, family 2, EMR1 hormone receptor
IPR001881 EGF-like calcium-binding domain
IPR003056 GPCR, family 2, CD97 antigen
IPR017981 GPCR, family 2-like

PFAM

PF01825
PF00008
PF00002
PF07645

PRINTS

PR00249
PR01128
PR01278

PIRSF

SMART

SM00303
SM00181
SM00179

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt