InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Arnt

Summary

InnateDB Protein

IDBP-172690.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Arnt

Protein Name

aryl hydrocarbon receptor nuclear translocator

Synonyms

bHLHe2; D3Ertd557e; Drnt; ESTM42; Hif1b; mKIAA4051; W08714;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099810

InnateDB Gene

IDBG-172688 (Arnt)

Protein Structure

UniProt Annotation

Function

Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 45 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	21 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	45 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000989	transcription factor binding transcription factor activity
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0004871	signal transducer activity
GO:0004874	aryl hydrocarbon receptor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0017162	aryl hydrocarbon receptor binding
GO:0035326	enhancer binding
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity
GO:0046983	protein dimerization activity

Biological Process

GO:0001666	response to hypoxia
GO:0001892	embryonic placenta development
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007165	signal transduction
GO:0009636	response to toxic substance
GO:0010575	positive regulation vascular endothelial growth factor production
GO:0030154	cell differentiation
GO:0030522	intracellular receptor signaling pathway
GO:0033235	positive regulation of protein sumoylation
GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046886	positive regulation of hormone biosynthetic process

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:88071

InterPro

IPR000014 PAS domain
IPR001067 Nuclear translocator
IPR001610 PAC motif
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
IPR013655 PAS fold-3
IPR013767 PAS fold

PFAM

PF13188
PF13426
PF00010
PF08447
PF00989

PRINTS

PR00785

PIRSF

SMART

SM00091
SM00086
SM00353

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt