InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Arnt

Summary

InnateDB Gene

IDBG-172688.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Arnt

Gene Name

aryl hydrocarbon receptor nuclear translocator

Synonyms

bHLHe2; D3Ertd557e; Drnt; ESTM42; Hif1b; mKIAA4051; W08714

Species

Mus musculus

Ensembl Gene

ENSMUSG00000015522

Encoded Proteins

IDBP-172690

aryl hydrocarbon receptor nuclear translocator

IDBP-172692

aryl hydrocarbon receptor nuclear translocator

IDBP-172694

aryl hydrocarbon receptor nuclear translocator

IDBP-267253

aryl hydrocarbon receptor nuclear translocator

IDBP-267255

aryl hydrocarbon receptor nuclear translocator

IDBP-534904

aryl hydrocarbon receptor nuclear translocator

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143437:
The aryl hydrocarbon (Ah) receptor is involved in the induction of several enzymes that participate in xenobiotic metabolism. The ligand-free, cytosolic form of the Ah receptor is complexed to heat shock protein 90. Binding of ligand, which includes dioxin and polycyclic aromatic hydrocarbons, results in translocation of the ligand-binding subunit only to the nucleus. Induction of enzymes involved in xenobiotic metabolism occurs through binding of the ligand-bound Ah receptor to xenobiotic responsive elements in the promoters of genes for these enzymes. This gene encodes a protein that forms a complex with the ligand-bound Ah receptor, and is required for receptor function. The encoded protein has also been identified as the beta subunit of a heterodimeric transcription factor, hypoxia-inducible factor 1. A t(1;12)(q21;p13) translocation, which results in a TEL-ARNT fusion protein, is associated with acute myeloblastic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2010]
This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1. Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:95434388-95497240

Strand

Forward strand

Band

F2.1

Transcripts

ENSMUST00000102749	ENSMUSP00000099810
ENSMUST00000015666	ENSMUSP00000015666
ENSMUST00000090804	ENSMUSP00000088313
ENSMUST00000107161	ENSMUSP00000102779
ENSMUST00000107160	ENSMUSP00000102778
ENSMUST00000147765
ENSMUST00000149051
ENSMUST00000156653
ENSMUST00000140060
ENSMUST00000136413	ENSMUSP00000116688
ENSMUST00000147094

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 45 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	21 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	45 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000989	transcription factor binding transcription factor activity
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0004871	signal transducer activity
GO:0004874	aryl hydrocarbon receptor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0017162	aryl hydrocarbon receptor binding
GO:0035326	enhancer binding
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity
GO:0046983	protein dimerization activity

Biological Process

GO:0001666	response to hypoxia
GO:0001892	embryonic placenta development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007165	signal transduction
GO:0009636	response to toxic substance
GO:0010575	positive regulation vascular endothelial growth factor production
GO:0030154	cell differentiation
GO:0030522	intracellular receptor signaling pathway
GO:0033235	positive regulation of protein sumoylation
GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046886	positive regulation of hormone biosynthetic process