Mus musculus Gene: Arnt | |||||||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||||||
InnateDB Gene | IDBG-172688.6 | ||||||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||
Gene Symbol | Arnt | ||||||||||||||||||||||||||||||
Gene Name | aryl hydrocarbon receptor nuclear translocator | ||||||||||||||||||||||||||||||
Synonyms | bHLHe2; D3Ertd557e; Drnt; ESTM42; Hif1b; mKIAA4051; W08714 | ||||||||||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000015522 | ||||||||||||||||||||||||||||||
Encoded Proteins |
aryl hydrocarbon receptor nuclear translocator
aryl hydrocarbon receptor nuclear translocator
aryl hydrocarbon receptor nuclear translocator
aryl hydrocarbon receptor nuclear translocator
aryl hydrocarbon receptor nuclear translocator
aryl hydrocarbon receptor nuclear translocator
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Protein Structure | |||||||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143437:
The aryl hydrocarbon (Ah) receptor is involved in the induction of several enzymes that participate in xenobiotic metabolism. The ligand-free, cytosolic form of the Ah receptor is complexed to heat shock protein 90. Binding of ligand, which includes dioxin and polycyclic aromatic hydrocarbons, results in translocation of the ligand-binding subunit only to the nucleus. Induction of enzymes involved in xenobiotic metabolism occurs through binding of the ligand-bound Ah receptor to xenobiotic responsive elements in the promoters of genes for these enzymes. This gene encodes a protein that forms a complex with the ligand-bound Ah receptor, and is required for receptor function. The encoded protein has also been identified as the beta subunit of a heterodimeric transcription factor, hypoxia-inducible factor 1. A t(1;12)(q21;p13) translocation, which results in a TEL-ARNT fusion protein, is associated with acute myeloblastic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2010] This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1. Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013] |
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Gene Information | |||||||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||||||
Genomic Location | Chromosome 3:95434388-95497240 | ||||||||||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||||||||||
Band | F2.1 | ||||||||||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 45 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||||||||
REACTOME |
Cellular responses to stress pathway
Cellular response to hypoxia pathway
Regulation of Hypoxia-inducible Factor (HIF) by oxygen pathway
Regulation of gene expression by Hypoxia-inducible Factor pathway
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KEGG |
Renal cell carcinoma pathway
Pathways in cancer pathway
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INOH | |||||||||||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||||||
NETPATH |
AndrogenReceptor pathway
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REACTOME |
Regulation of gene expression by Hypoxia-inducible Factor pathway
Cellular responses to stress pathway
Regulation of Hypoxia-inducible Factor (HIF) by oxygen pathway
Cellular response to hypoxia pathway
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KEGG |
Renal cell carcinoma pathway
Pathways in cancer pathway
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INOH | |||||||||||||||||||||||||||||||
PID NCI |
Notch-mediated HES/HEY network
HIF-2-alpha transcription factor network
HIF-1-alpha transcription factor network
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
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Cross-References | |||||||||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||||||
UniGene | Mm.250265 Mm.391772 Mm.408872 | ||||||||||||||||||||||||||||||
RefSeq | NM_001037737 NM_009709 XM_006500930 XM_006500931 XM_006500932 XM_006500933 | ||||||||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||||||||
CCDS | CCDS17614 CCDS38546 | ||||||||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||||||||||
MGI Symbol | |||||||||||||||||||||||||||||||
EMBL | |||||||||||||||||||||||||||||||
GenPept | |||||||||||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||||||||||