InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Arnt

Summary

InnateDB Protein

IDBP-172694.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Arnt

Protein Name

aryl hydrocarbon receptor nuclear translocator

Synonyms

bHLHe2; D3Ertd557e; Drnt; ESTM42; Hif1b; mKIAA4051; W08714;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000088313

InnateDB Gene

IDBG-172688 (Arnt)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 45 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	21 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	45 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000989	transcription factor binding transcription factor activity
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0004871	signal transducer activity
GO:0004874	aryl hydrocarbon receptor activity
GO:0005515	protein binding
GO:0017162	aryl hydrocarbon receptor binding
GO:0035326	enhancer binding
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity
GO:0046983	protein dimerization activity

Biological Process

GO:0001666	response to hypoxia
GO:0001892	embryonic placenta development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007165	signal transduction
GO:0009636	response to toxic substance
GO:0010575	positive regulation vascular endothelial growth factor production
GO:0030154	cell differentiation
GO:0030522	intracellular receptor signaling pathway
GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046886	positive regulation of hormone biosynthetic process

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:88071

InterPro

IPR000014 PAS domain
IPR001067 Nuclear translocator
IPR001610 PAC motif
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
IPR013655 PAS fold-3
IPR013767 PAS fold

PFAM

PF13188
PF13426
PF00010
PF08447
PF00989

PRINTS

PR00785

PIRSF

SMART

SM00091
SM00086
SM00353

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt