Version 5.4
Mus musculus Protein: Eif4e3
Summary
InnateDB Protein IDBP-172807.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Eif4e3
Protein Name eukaryotic translation initiation factor 4E member 3
Synonyms 1300018P11Rik; AI451927; eIF4E-3;
Species Mus musculus
Ensembl Protein ENSMUSP00000032151
InnateDB Gene IDBG-703896 (Eif4e3)
Protein Structure
UniProt Annotation
Function Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis. May act as an inhibitor of EIF4E1 activity. {ECO:0000269PubMed:15153109}.
Subcellular Localization
Disease Associations
Tissue Specificity Only expressed in heart, skeletal muscle, lung and spleen. {ECO:0000269PubMed:15153109}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0003723 RNA binding
GO:0003743 translation initiation factor activity
Biological Process
GO:0006413 translational initiation
GO:0006417 regulation of translation
GO:0008150 biological_process
Cellular Component
GO:0005575 cellular_component
GO:0005737 cytoplasm
GO:0005845 mRNA cap binding complex
Protein Structure and Domains
PDB ID MGI:1914142
InterPro IPR001040 Translation Initiation factor eIF- 4e
IPR023398 Translation Initiation factor eIF- 4e-like domain
PFAM PF01652
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9DBB5
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 66892
UniGene Mm.407252
RefSeq NP_080105
MGI ID 4B6V
MGI Symbol Eif4e3
OMIM
CCDS CCDS20386
HPRD
IMGT
EMBL AK005054 AK007268 AY628329 BC027014
GenPept AAH27014 AAT45741 BAB23780 BAB24928

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca