InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Plxnb2

Summary

InnateDB Protein

IDBP-172824.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Plxnb2

Protein Name

plexin B2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000051731

InnateDB Gene

IDBG-172822 (Plxnb2)

Protein Structure

UniProt Annotation

Function

Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling. Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development. Regulates the migration of cerebellar granule cells in the developing brain. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May modulate the activity of RAC1 and CDC42. Down-regulates macrophage migration in wound- healing assays (in vitro). {ECO:0000269PubMed:17554007, ECO:0000269PubMed:19948886, ECO:0000269PubMed:21122816, ECO:0000269PubMed:21966369}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:21966369}; Single-pass type I membrane protein {ECO:0000269PubMed:21966369}.

Disease Associations

Tissue Specificity

Detected in macrophages from spleen and bone marrow (at protein level). Detected in granule cells in the developing cerebellum, dentate gyrus and olfactory bulb. {ECO:0000269PubMed:17554007, ECO:0000269PubMed:21966369}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0017154	semaphorin receptor activity

Biological Process

GO:0001843	neural tube closure
GO:0001932	regulation of protein phosphorylation
GO:0007165	signal transduction
GO:0007275	multicellular organismal development
GO:0007405	neuroblast proliferation
GO:0007420	brain development
GO:0008360	regulation of cell shape
GO:0032319	regulation of Rho GTPase activity
GO:0050772	positive regulation of axonogenesis
GO:0071526	semaphorin-plexin signaling pathway
GO:2001222	regulation of neuron migration

Cellular Component

GO:0005622	intracellular
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:2154239

InterPro

IPR001627 Sema domain
IPR002165 Plexin
IPR002909 IPT domain
IPR008936 Rho GTPase activation protein
IPR013548 Plexin, cytoplasmic RasGAP domain
IPR014756 Immunoglobulin E-set
IPR016201 Plexin-like fold

PFAM

PF01403
PF01437
PF01833
PF08337

PRINTS

PIRSF

SMART

SM00630
SM00429
SM00423

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

B2RXS4