Version 5.4
Mus musculus Gene: Plxnb2
Summary
InnateDB Gene IDBG-172822.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Plxnb2
Gene Name plexin B2
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000036606
Encoded Proteins
IDBP-172824
plexin B2
IDBP-262598
plexin B2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196576:
Members of the B class of plexins, such as PLXNB2 are transmembrane receptors that participate in axon guidance and cell migration in response to semaphorins (Perrot et al. (2002) [PubMed 12183458]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:89155549-89171120
Strand Reverse strand
Band E3
Transcripts
ENSMUST00000060808 ENSMUSP00000051731
ENSMUST00000109331 ENSMUSP00000104955
ENSMUST00000143014
ENSMUST00000151418
ENSMUST00000139372
ENSMUST00000131062
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
GO:0017154 semaphorin receptor activity
Biological Process
GO:0001843 neural tube closure
GO:0001932 regulation of protein phosphorylation
GO:0007165 signal transduction
GO:0007275 multicellular organismal development
GO:0007405 neuroblast proliferation
GO:0007420 brain development
GO:0008360 regulation of cell shape
GO:0032319 regulation of Rho GTPase activity
GO:0050772 positive regulation of axonogenesis
GO:0071526 semaphorin-plexin signaling pathway
GO:2001222 regulation of neuron migration
Cellular Component
GO:0005622 intracellular
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000196576
View Gene Order
ENSBTAG00000014966
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04360
Axon guidance pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04360
Axon guidance pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.486164
RefSeq NM_001159521 NM_001284506 NM_138749 XM_006520412 XM_006520413 XM_006520414
OMIM
CCDS CCDS49698
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca