InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EIF4EBP1

Summary

InnateDB Protein

IDBP-17286.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EIF4EBP1

Protein Name

eukaryotic translation initiation factor 4E binding protein 1

Synonyms

4E-BP1; 4EBP1; BP-1; PHAS-I;

Species

Homo sapiens

Ensembl Protein

ENSP00000340691

InnateDB Gene

IDBG-17284 (EIF4EBP1)

Protein Structure

UniProt Annotation

Function

Regulates eIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. {ECO:0000269PubMed:22578813, ECO:0000269PubMed:7935836}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	49 [view]
Protein-Protein	49 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008190	eukaryotic initiation factor 4E binding
GO:0030371	translation repressor activity
GO:0031369	translation initiation factor binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0002931	response to ischemia
GO:0006412	translation
GO:0006413	translational initiation
GO:0008286	insulin receptor signaling pathway
GO:0010467	gene expression
GO:0030324	lung development
GO:0031333	negative regulation of protein complex assembly
GO:0031929	TOR signaling
GO:0044267	cellular protein metabolic process
GO:0045471	response to ethanol
GO:0045931	positive regulation of mitotic cell cycle
GO:0045947	negative regulation of translational initiation