InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hormad1

Summary

InnateDB Protein

IDBP-172931.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hormad1

Protein Name

HORMA domain containing 1

Synonyms

4921522K05Rik; Nohma;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029754

InnateDB Gene

IDBG-172927 (Hormad1)

Protein Structure

UniProt Annotation

Function

Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. {ECO:0000269PubMed:19686734, ECO:0000269PubMed:21079677, ECO:0000269PubMed:21478856}.

Subcellular Localization

Isoform 1: Nucleus. Chromosome. Note=Preferentially localizes to unsynapsed or desynapsed chromosomal regions during the prophase I stage of meiosis. Accumulates on the chromosomes during the leptotene to zygotene stages of meiotic prophase I. As germ cells progress into the pachytene stage, disappears from the synapsed chromosomal regions. Once the chromosomes desynapse during the diplotene stage, it again accumulates on the chromosome axis of the desynapsed homologs. TRIP13 is required for depletion from synapsed chromosomes. The expression of the phosphorylated form at Ser-375 is restricted to unsynapsed chromosomal regions.Isoform 2: Cytoplasm.

Disease Associations

Tissue Specificity

Specifically expressed in meiotic germ cells. {ECO:0000269PubMed:15567723, ECO:0000269PubMed:19686734, ECO:0000269PubMed:19851446, ECO:0000269PubMed:21079677}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0001824	blastocyst development
GO:0007126	meiotic nuclear division
GO:0007130	synaptonemal complex assembly
GO:0007283	spermatogenesis
GO:0042138	meiotic DNA double-strand break formation
GO:0048477	oogenesis
GO:0051177	meiotic sister chromatid cohesion
GO:0051598	meiotic recombination checkpoint
GO:0060629	regulation of homologous chromosome segregation