InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Acsl6

Summary

InnateDB Protein

IDBP-172966.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Acsl6

Protein Name

acyl-CoA synthetase long-chain family member 6

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000072040

InnateDB Gene

IDBG-172962 (Acsl6)

Protein Structure

UniProt Annotation

Function

Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion outer membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Peroxisome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Microsome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004467	long-chain fatty acid-CoA ligase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0019899	enzyme binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0001666	response to hypoxia
GO:0001676	long-chain fatty acid metabolic process
GO:0006641	triglyceride metabolic process
GO:0007405	neuroblast proliferation
GO:0007584	response to nutrient
GO:0008152	metabolic process
GO:0008654	phospholipid biosynthetic process
GO:0009629	response to gravity
GO:0010747	positive regulation of plasma membrane long-chain fatty acid transport
GO:0010867	positive regulation of triglyceride biosynthetic process
GO:0010976	positive regulation of neuron projection development
GO:0015908	fatty acid transport
GO:0032869	cellular response to insulin stimulus
GO:0048545	response to steroid hormone
GO:0048666	neuron development

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005778	peroxisomal membrane
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane