InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Acsl6

Summary

InnateDB Gene

IDBG-172962.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Acsl6

Gene Name

acyl-CoA synthetase long-chain family member 6

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020333

Encoded Proteins

IDBP-172964

acyl-CoA synthetase long-chain family member 6

IDBP-172966

acyl-CoA synthetase long-chain family member 6

IDBP-172968

acyl-CoA synthetase long-chain family member 6

IDBP-172970

acyl-CoA synthetase long-chain family member 6

IDBP-172972

acyl-CoA synthetase long-chain family member 6

IDBP-172974

acyl-CoA synthetase long-chain family member 6

IDBP-172976

acyl-CoA synthetase long-chain family member 6

IDBP-263533

acyl-CoA synthetase long-chain family member 6

IDBP-263535

acyl-CoA synthetase long-chain family member 6

IDBP-263543

acyl-CoA synthetase long-chain family member 6

IDBP-534285

acyl-CoA synthetase long-chain family member 6

IDBP-539327

acyl-CoA synthetase long-chain family member 6

IDBP-535838

acyl-CoA synthetase long-chain family member 6

IDBP-540014

acyl-CoA synthetase long-chain family member 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164398:
The protein encoded by this gene catalyzes the formation of acyl-CoA from fatty acids, ATP, and CoA, using magnesium as a cofactor. The encoded protein plays a major role in fatty acid metabolism in the brain. Translocations with the ETV6 gene are causes of myelodysplastic syndrome with basophilia, acute myelogenous leukemia with eosinophilia, and acute eosinophilic leukemia. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:54303798-54364756

Strand

Forward strand

Band

B1.3

Transcripts

ENSMUST00000093106	ENSMUSP00000090795
ENSMUST00000072178	ENSMUSP00000072040
ENSMUST00000094194	ENSMUSP00000091746
ENSMUST00000101213	ENSMUSP00000098773
ENSMUST00000101211	ENSMUSP00000098771
ENSMUST00000064690	ENSMUSP00000069844
ENSMUST00000000145	ENSMUSP00000000145
ENSMUST00000108905	ENSMUSP00000104533
ENSMUST00000108904	ENSMUSP00000104532
ENSMUST00000108899	ENSMUSP00000104527
ENSMUST00000138515	ENSMUSP00000117128
ENSMUST00000149403	ENSMUSP00000120540
ENSMUST00000156252	ENSMUSP00000119714
ENSMUST00000127731
ENSMUST00000139484	ENSMUSP00000120693

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004467	long-chain fatty acid-CoA ligase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0019899	enzyme binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0001666	response to hypoxia
GO:0001676	long-chain fatty acid metabolic process
GO:0006641	triglyceride metabolic process
GO:0007405	neuroblast proliferation
GO:0007584	response to nutrient
GO:0008152	metabolic process
GO:0008654	phospholipid biosynthetic process
GO:0009629	response to gravity
GO:0010747	positive regulation of plasma membrane long-chain fatty acid transport
GO:0010867	positive regulation of triglyceride biosynthetic process
GO:0010976	positive regulation of neuron projection development
GO:0015908	fatty acid transport
GO:0032869	cellular response to insulin stimulus
GO:0048545	response to steroid hormone
GO:0048666	neuron development

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005778	peroxisomal membrane
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane