InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: C4b

Summary

InnateDB Protein

IDBP-173024.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

C4b

Protein Name

complement component 4B (Childo blood group)

Synonyms

C4; Ss;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000069418

InnateDB Gene

IDBG-173022 (C4b)

Protein Structure

UniProt Annotation

Function

Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. Catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004866	endopeptidase inhibitor activity
GO:0005515	protein binding

Biological Process

GO:0006954	inflammatory response
GO:0006958	complement activation, classical pathway
GO:0010951	negative regulation of endopeptidase activity
GO:0045087	innate immune response

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space

Protein Structure and Domains

PDB ID

MGI:88228

InterPro

IPR000020 Anaphylatoxin/fibulin
IPR001134 Netrin domain
IPR001599 Alpha-2-macroglobulin
IPR001840 Anaphylatoxin, complement system domain
IPR002890 Alpha-2-macroglobulin, N-terminal
IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
IPR009048 Alpha-macroglobulin, receptor-binding
IPR011625 Alpha-2-macroglobulin, N-terminal 2
IPR011626 Alpha-macroglobulin complement component
IPR018081 Anaphylatoxin, complement system
IPR018933 Netrin module, non-TIMP type
IPR019565 Alpha-2-macroglobulin, thiol-ester bond-forming

PFAM