InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ensa

Summary

InnateDB Protein

IDBP-173175.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ensa

Protein Name

endosulfine alpha

Synonyms

1700020C18Rik; 2610007F17Rik; AI451924;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000045937

InnateDB Gene

IDBG-173173 (Ensa)

Protein Structure

UniProt Annotation

Function

Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Present in striatum (at protein level). {ECO:0000269PubMed:11279279}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004864	protein phosphatase inhibitor activity
GO:0008601	protein phosphatase type 2A regulator activity
GO:0019212	phosphatase inhibitor activity
GO:0051721	protein phosphatase 2A binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0007067	mitotic nuclear division
GO:0009749	response to glucose
GO:0043086	negative regulation of catalytic activity
GO:0050790	regulation of catalytic activity