InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ensa

Summary

InnateDB Gene

IDBG-173173.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ensa

Gene Name

endosulfine alpha

Synonyms

1700020C18Rik; 2610007F17Rik; AI451924

Species

Mus musculus

Ensembl Gene

ENSMUSG00000038619

Encoded Proteins

IDBP-142914

endosulfine alpha

IDBP-173175

endosulfine alpha

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143420:
The protein encoded by this gene belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes. At least eight alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:95624980-95632102

Strand

Forward strand

Band

F2.1

Transcripts

ENSMUST00000058230	ENSMUSP00000051799
ENSMUST00000037983	ENSMUSP00000045937

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004864	protein phosphatase inhibitor activity
GO:0005102	receptor binding
GO:0008601	protein phosphatase type 2A regulator activity
GO:0019212	phosphatase inhibitor activity
GO:0019870	potassium channel inhibitor activity
GO:0051721	protein phosphatase 2A binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0007067	mitotic nuclear division
GO:0009749	response to glucose
GO:0043086	negative regulation of catalytic activity
GO:0050790	regulation of catalytic activity
GO:0050796	regulation of insulin secretion