InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pdzrn3

Summary

InnateDB Protein

IDBP-173207.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pdzrn3

Protein Name

PDZ domain containing RING finger 3

Synonyms

1110020C07Rik; AI429718; AL023082; LNX3; SEMACAP3; Semcap3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000075376

InnateDB Gene

IDBG-173205 (Pdzrn3)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase. Plays an important role in regulating the surface level of MUSK on myotubes. Mediates the ubiquitination of MUSK, promoting its endocytosis and lysosomal degradation. Might contribute to terminal myogenic differentiation. {ECO:0000269PubMed:17118964, ECO:0000269PubMed:17576800}.

Subcellular Localization

Disease Associations

Tissue Specificity

Highly expressed in skeletal and cardiac muscle and at lower levels in spinal cord and brain (at protein level). Also expressed in kidney and lung. In muscles, concentrated at the neuromuscular junction (NMJ). {ECO:0000269PubMed:17576800}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding