InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pkm

Summary

InnateDB Protein

IDBP-173278.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pkm

Protein Name

pyruvate kinase, muscle

Synonyms

AA414905; AL024370; AL024424; Pk-2; Pk-3; Pk3; Pkm2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034834

InnateDB Gene

IDBG-173276 (Pkm)

Protein Structure

UniProt Annotation

Function

Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Embryonic stem cells and embryonal carcinoma cells. {ECO:0000269PubMed:18191611}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 77 interaction(s) predicted by orthology.

Experimentally validated
Total	37 [view]
Protein-Protein	37 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	77 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0003824	catalytic activity
GO:0004743	pyruvate kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0023026	MHC class II protein complex binding
GO:0030955	potassium ion binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006096	glycolytic process
GO:0012501	programmed cell death
GO:0016310	phosphorylation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005886	plasma membrane
GO:0005929	cilium
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:97591

InterPro

IPR001697 Pyruvate kinase
IPR011037 Pyruvate kinase-like, insert domain
IPR015793 Pyruvate kinase, barrel
IPR015795 Pyruvate kinase, C-terminal
IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain

PFAM

PF00224
PF02887

PRINTS

PR01050

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P52480