InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pkm

Summary

InnateDB Gene

IDBG-173276.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pkm

Gene Name

pyruvate kinase, muscle

Synonyms

AA414905; AL024370; AL024424; Pk-2; Pk-3; Pk3; Pkm2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032294

Encoded Proteins

IDBP-173278

pyruvate kinase, muscle

IDBP-627005

pyruvate kinase, muscle

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000067225:
This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported. [provided by RefSeq, May 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:59656368-59679375

Strand

Forward strand

Band

Transcripts

ENSMUST00000034834	ENSMUSP00000034834
ENSMUST00000163694	ENSMUSP00000128770

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 77 interaction(s) predicted by orthology.

Experimentally validated
Total	37 [view]
Protein-Protein	37 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	77 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0003824	catalytic activity
GO:0004743	pyruvate kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0023026	MHC class II protein complex binding
GO:0030955	potassium ion binding
GO:0044822	poly(A) RNA binding