InnateDB Protein
|
IDBP-173324.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Cep135
|
Protein Name
|
centrosomal protein 135
|
Synonyms
|
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000038674
|
InnateDB Gene
|
IDBG-173322 (Cep135)
|
Protein Structure
|
|
Function |
Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole (By similarity). {ECO:0000250}.
|
Subcellular Localization |
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269PubMed:11781336}. Note=During centriole biogenesis, it is concentrated within the proximal lumen of both parental centrioles and procentrioles. {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated |
Total |
5
[view]
|
Protein-Protein |
5
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
6 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
MGI:2681869
|
InterPro |
IPR004953
EB1, C-terminal
IPR009053
Prefoldin
|
PFAM |
PF03271
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q6P5D4
|
PhosphoSite |
PhosphoSite-Q6P5D4
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
381644
|
UniGene |
Mm.332452
|
RefSeq |
NP_950197
|
MGI ID |
|
MGI Symbol |
Cep135
|
OMIM |
|
CCDS |
CCDS19365
|
HPRD |
|
IMGT |
|
EMBL |
AK172988
BC062951
|
GenPept |
AAH62951
BAD32266
|
|
|