Version 5.4
Mus musculus Gene: Cep135
Summary
InnateDB Gene IDBG-173322.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cep135
Gene Name centrosomal protein 135
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000036403
Encoded Proteins
IDBP-173324
centrosomal protein 135
IDBP-400779
centrosomal protein 135
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000174799:
This gene encodes a centrosomal protein, which acts as a scaffolding protein during early centriole biogenesis, and is also required for centriole-centriole cohesion during interphase. Mutations in this gene are associated with autosomal recessive primary microcephaly-8. [provided by RefSeq, Jun 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:76588698-76646466
Strand Forward strand
Band C3.3
Transcripts
ENSMUST00000049060 ENSMUSP00000038674
ENSMUST00000121979 ENSMUSP00000112602
ENSMUST00000130651
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0008022 protein C-terminus binding
Biological Process
GO:0007099 centriole replication
GO:0010457 centriole-centriole cohesion
Cellular Component
GO:0005813 centrosome
GO:0005814 centriole
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000174799
View Gene Order
ENSBTAG00000009471
Not yet available
Pathways
NETPATH
REACTOME
REACT_245720
Recruitment of mitotic centrosome proteins and complexes pathway
REACT_240530
G2/M Transition pathway
REACT_249770
Cell Cycle, Mitotic pathway
REACT_243078
Loss of Nlp from mitotic centrosomes pathway
REACT_188804
Cell Cycle pathway
REACT_246508
Mitotic G2-G2/M phases pathway
REACT_244487
Loss of proteins required for interphase microtubule organization� from the centrosome pathway
REACT_196635
Regulation of PLK1 Activity at G2/M Transition pathway
REACT_253753
Centrosome maturation pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_160315
Regulation of PLK1 Activity at G2/M Transition pathway
REACT_15364
Loss of Nlp from mitotic centrosomes pathway
REACT_15451
Loss of proteins required for interphase microtubule organization� from the centrosome pathway
REACT_15296
Recruitment of mitotic centrosome proteins and complexes pathway
REACT_115566
Cell Cycle pathway
REACT_15479
Centrosome maturation pathway
REACT_2203
G2/M Transition pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_21391
Mitotic G2-G2/M phases pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q6P5D4
TrEMBL
UniProt Splice Variant
Entrez Gene 381644
UniGene Mm.332452
RefSeq NM_199032 XM_006535023 XM_006535024 XM_006535026 XM_006535027 XM_006535028
OMIM
CCDS CCDS19365
HPRD
IMGT
MGI ID MGI:2681869
MGI Symbol Cep135
EMBL AK172988 BC062951
GenPept AAH62951 BAD32266
RNA Seq Atlas 381644

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca