InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Plp1

Summary

InnateDB Protein

IDBP-173394.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Plp1

Protein Name

proteolipid protein (myelin) 1

Synonyms

DM20; jimpy; jp; msd; Plp; rsh;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033800

InnateDB Gene

IDBG-173392 (Plp1)

Protein Structure

UniProt Annotation

Function

This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:17634366}; Multi-pass membrane protein {ECO:0000269PubMed:17634366}. Myelin membrane {ECO:0000269PubMed:17634366}. Note=Colocalizes with SIRT2 in internodal regions, at paranodal axoglial junction and Schmidt-Lanterman incisures of myelin sheat.

Disease Associations

Note=Defects in Plp1 are the cause of the dysmyelinating diseases Jimpy and Rumpshaker (rsh).

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0005515	protein binding
GO:0019911	structural constituent of myelin sheath

Biological Process

GO:0006954	inflammatory response
GO:0007229	integrin-mediated signaling pathway
GO:0008366	axon ensheathment
GO:0010001	glial cell differentiation
GO:0010628	positive regulation of gene expression
GO:0014002	astrocyte development
GO:0021762	substantia nigra development
GO:0022010	central nervous system myelination
GO:0042552	myelination
GO:0042759	long-chain fatty acid biosynthetic process
GO:0048469	cell maturation
GO:0061564	axon development