InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Plp1

Summary

InnateDB Gene

IDBG-173392.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Plp1

Gene Name

proteolipid protein (myelin) 1

Synonyms

DM20; jimpy; jp; msd; Plp; rsh

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031425

Encoded Proteins

IDBP-173394

proteolipid protein (myelin) 1

IDBP-254626

proteolipid protein (myelin) 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000123560:
This gene encodes a transmembrane proteolipid protein that is the predominant myelin protein present in the central nervous system. It may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause X-linked Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively spliced transcript variants encoding distinct isoforms or having different 5' UTRs, have been identified for this gene. [provided by RefSeq, Jul 2008]
This gene encodes a transmembrane proteolipid protein that is the predominant myelin protein present in the central nervous system. It may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause X-linked Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively spliced transcript variants encoding distinct isoforms or having different 5\' UTRs, have been identified for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:136822671-136839733

Strand

Forward strand

Band

Transcripts

ENSMUST00000033800	ENSMUSP00000033800
ENSMUST00000113085	ENSMUSP00000108708
ENSMUST00000125644
ENSMUST00000144880

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0005515	protein binding
GO:0019911	structural constituent of myelin sheath

Biological Process

GO:0006954	inflammatory response
GO:0007229	integrin-mediated signaling pathway
GO:0008366	axon ensheathment
GO:0010001	glial cell differentiation
GO:0010628	positive regulation of gene expression
GO:0014002	astrocyte development
GO:0021762	substantia nigra development
GO:0022010	central nervous system myelination
GO:0042552	myelination
GO:0042759	long-chain fatty acid biosynthetic process
GO:0048469	cell maturation
GO:0061564	axon development

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0043209	myelin sheath

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000123560

View Gene Order

ENSBTAG00000006977

Not yet available

Cross-References

SwissProt

P60202

TrEMBL

Q3UYM8

UniProt Splice Variant

Entrez Gene

18823

UniGene

Mm.385414 Mm.44535 Mm.445407 Mm.474602 Mm.474648

RefSeq

NM_011123 NM_001290561 XM_006528513

OMIM

CCDS

CCDS30424 CCDS72436

HPRD

IMGT

MGI ID

MGI:97623

MGI Symbol

Plp1

EMBL

AK134554 AK160872 BC027010 M14674 M15442 M16472 M37329 M37330 M37331 M37332 M37333 M37334 M37335 X06375 X07215 X07216 X07217 X07218 X07219 X07220 X07221

GenPept

AAA39950 AAA39951 AAA39952 AAA39953 AAA39954 AAA39955 AAH27010 BAE22184 BAE36061 CAA30184 CAB40821

RNA Seq Atlas

18823