InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Bag5

Summary

InnateDB Protein

IDBP-173487.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bag5

Protein Name

BCL2-associated athanogene 5

Synonyms

1600025G07Rik; 4930405J06Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000051049

InnateDB Gene

IDBG-173485 (Bag5)

Protein Structure

UniProt Annotation

Function

May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding. Inhibits both auto-ubiquitination of PARK2 and ubiquitination of target proteins by PARK2 (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0031625	ubiquitin protein ligase binding
GO:0051087	chaperone binding

Biological Process

GO:0031397	negative regulation of protein ubiquitination
GO:0051444	negative regulation of ubiquitin-protein transferase activity
GO:0061084	negative regulation of protein refolding
GO:0070997	neuron death
GO:0090083	regulation of inclusion body assembly