InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Irs1

Summary

InnateDB Protein

IDBP-173591.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Irs1

Protein Name

insulin receptor substrate 1

Synonyms

G972R; IRS-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000063795

InnateDB Gene

IDBG-173589 (Irs1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 55 interaction(s) predicted by orthology.

Experimentally validated
Total	27 [view]
Protein-Protein	26 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	55 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005158	insulin receptor binding
GO:0005159	insulin-like growth factor receptor binding
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0043548	phosphatidylinositol 3-kinase binding

Biological Process

GO:0002053	positive regulation of mesenchymal cell proliferation
GO:0008286	insulin receptor signaling pathway
GO:0010468	regulation of gene expression
GO:0010907	positive regulation of glucose metabolic process
GO:0014065	phosphatidylinositol 3-kinase signaling
GO:0016042	lipid catabolic process
GO:0030335	positive regulation of cell migration
GO:0030879	mammary gland development
GO:0032000	positive regulation of fatty acid beta-oxidation
GO:0032868	response to insulin
GO:0032869	cellular response to insulin stimulus
GO:0034504	protein localization to nucleus
GO:0043491	protein kinase B signaling
GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity
GO:0045725	positive regulation of glycogen biosynthetic process
GO:0046326	positive regulation of glucose import
GO:0046676	negative regulation of insulin secretion
GO:0048009	insulin-like growth factor receptor signaling pathway
GO:2001275	positive regulation of glucose import in response to insulin stimulus