InnateDB Protein
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IDBP-17363.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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DPP8
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Protein Name
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dipeptidyl-peptidase 8
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000318111
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InnateDB Gene
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IDBG-17359 (DPP8)
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Protein Structure
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Function |
Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2. May play a role in T-cell activation and immune function. {ECO:0000269PubMed:11012666}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:11012666, ECO:0000269PubMed:12534281, ECO:0000269PubMed:12662155}.
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Disease Associations |
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Tissue Specificity |
Ubiquitously expressed, with highest levels in testis, placenta, prostate, muscle and brain. {ECO:0000269PubMed:11012666, ECO:0000269PubMed:12662155}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
17
[view]
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Protein-Protein |
16
[view]
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Protein-DNA |
0
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0008236
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serine-type peptidase activity
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GO:0008239
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dipeptidyl-peptidase activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001375
Peptidase S9, prolyl oligopeptidase, catalytic domain
IPR002469
Peptidase S9B, dipeptidylpeptidase IV N-terminal
IPR029058
Alpha/Beta hydrolase fold
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PFAM |
PF00326
PF00930
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q6V1X1
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PhosphoSite |
PhosphoSite-Q6V1X1
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TrEMBL |
H0YN53
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UniProt Splice Variant |
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Entrez Gene |
54878
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UniGene |
Hs.623476
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RefSeq |
NP_932065
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HUGO |
HGNC:16490
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OMIM |
606819
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CCDS |
CCDS10208
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HPRD |
07076
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IMGT |
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EMBL |
AC011846
AC105129
AF173382
AF175225
AF176779
AF221634
AF221635
AF221636
AF221637
AK000290
AK027826
AY172659
AY354202
BC030688
BC040203
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GenPept |
AAG29766
AAG29767
AAG29768
AAG29769
AAH30688
AAO17261
AAQ13623
AAQ13650
AAQ13657
AAQ63887
BAA91059
BAB55395
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