Version 5.4
Homo sapiens Gene: DPP8
Summary
InnateDB Gene IDBG-17359.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DPP8
Gene Name dipeptidyl-peptidase 8
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000074603
Encoded Proteins
IDBP-17361
dipeptidyl-peptidase 8
IDBP-17363
dipeptidyl-peptidase 8
IDBP-17365
dipeptidyl-peptidase 8
IDBP-17367
dipeptidyl-peptidase 8
IDBP-239074
dipeptidyl-peptidase 8
IDBP-747352
IDBP-600034
dipeptidyl-peptidase 8
IDBP-595524
dipeptidyl-peptidase 8
IDBP-746921
IDBP-596257
dipeptidyl-peptidase 8
IDBP-585080
dipeptidyl-peptidase 8
IDBP-598035
dipeptidyl-peptidase 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the peptidase S9B family, a small family of dipeptidyl peptidases that are able to cleave peptide substrates at a prolyl bond. The encoded protein shares similarity with dipeptidyl peptidase IV in that it is ubiquitously expressed, and hydrolyzes the same substrates. These similarities suggest that, like dipeptidyl peptidase IV, this protein may play a role in T-cell activation and immune function. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:65442463-65517704
Strand Reverse strand
Band q22.31
Transcripts
ENST00000300141 ENSP00000300141
ENST00000321147 ENSP00000318111
ENST00000358939 ENSP00000351817
ENST00000341861 ENSP00000339208
ENST00000395652 ENSP00000379013
ENST00000558786 ENSP00000454922
ENST00000559233 ENSP00000453954
ENST00000560048
ENST00000558559 ENSP00000452643
ENST00000560597
ENST00000558363
ENST00000559526 ENSP00000455592
ENST00000558529 ENSP00000452719
ENST00000560436 ENSP00000453870
ENST00000560194
ENST00000560665 ENSP00000453756
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated
Total 17 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008236 serine-type peptidase activity
GO:0008239 dipeptidyl-peptidase activity
GO:0016787 hydrolase activity
Biological Process
GO:0006508 proteolysis
GO:0006955 immune response
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032393
View Gene Order
ENSBTAG00000014807
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.591106 Hs.599898 Hs.623476
RefSeq NM_017743 NM_130434 NM_197960 NM_197961 XM_005254500 XM_005254505 XM_006720587
HUGO
OMIM
CCDS CCDS10207 CCDS10208 CCDS10209 CCDS10210
HPRD 07076
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca