InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pde8b

Summary

InnateDB Protein

IDBP-173647.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pde8b

Protein Name

phosphodiesterase 8B

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000070465

InnateDB Gene

IDBG-173643 (Pde8b)

Protein Structure

UniProt Annotation

Function

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in specific signaling in the thyroid gland (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:18431404}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000156	two-component response regulator activity
GO:0003824	catalytic activity
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0000160	phosphorelay signal transduction system
GO:0006198	cAMP catabolic process
GO:0006355	regulation of transcription, DNA-templated
GO:0007165	signal transduction
GO:0035556	intracellular signal transduction
GO:0090032	negative regulation of steroid hormone biosynthetic process

Cellular Component

GO:0005575

cellular_component

Protein Structure and Domains

PDB ID

MGI:2443999

InterPro

IPR000014 PAS domain
IPR001789 Signal transduction response regulator, receiver domain
IPR002073 3\'5\'-cyclic nucleotide phosphodiesterase, catalytic domain
IPR003607 HD/PDEase domain
IPR011006 CheY-like superfamily
IPR013655 PAS fold-3
IPR013656 PAS fold-4
IPR013767 PAS fold
IPR013938 3\'5\'-cyclic nucleotide phosphodiesterase PDE8
IPR023088 3\'5\'-cyclic nucleotide phosphodiesterase

PFAM