Version 5.4
Mus musculus Gene: Pde8b
Summary
InnateDB Gene IDBG-173643.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pde8b
Gene Name phosphodiesterase 8B
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000021684
Encoded Proteins
IDBP-173645
phosphodiesterase 8B
IDBP-173647
phosphodiesterase 8B
IDBP-535204
phosphodiesterase 8B
IDBP-537038
phosphodiesterase 8B
IDBP-533486
phosphodiesterase 8B
IDBP-536269
phosphodiesterase 8B
IDBP-532722
phosphodiesterase 8B
IDBP-540491
phosphodiesterase 8B
IDBP-539707
phosphodiesterase 8B
IDBP-623450
phosphodiesterase 8B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000113231:
The protein encoded by this gene is a cyclic nucleotide phosphodiesterase (PDE) that catalyzes the hydrolysis of the second messenger cAMP. The encoded protein, which does not hydrolyze cGMP, is resistant to several PDE inhibitors. Defects in this gene are a cause of autosomal dominant striatal degeneration (ADSD). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:95024454-95250336
Strand Reverse strand
Band D1
Transcripts
ENSMUST00000022192 ENSMUSP00000022192
ENSMUST00000067082 ENSMUSP00000070465
ENSMUST00000162412 ENSMUSP00000124409
ENSMUST00000162670 ENSMUSP00000125237
ENSMUST00000162292 ENSMUSP00000124068
ENSMUST00000162882
ENSMUST00000162153 ENSMUSP00000124704
ENSMUST00000159608 ENSMUSP00000125191
ENSMUST00000160412
ENSMUST00000160957 ENSMUSP00000125115
ENSMUST00000162328
ENSMUST00000159598 ENSMUSP00000124447
ENSMUST00000162716
ENSMUST00000172104 ENSMUSP00000128987
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000156 two-component response regulator activity
GO:0003824 catalytic activity
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0000160 phosphorelay signal transduction system
GO:0006198 cAMP catabolic process
GO:0006355 regulation of transcription, DNA-templated
GO:0007165 signal transduction
GO:0008152 metabolic process
GO:0035556 intracellular signal transduction
GO:0046676 negative regulation of insulin secretion
GO:0090032 negative regulation of steroid hormone biosynthetic process
Cellular Component
GO:0005575 cellular_component
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000113231
View Gene Order
ENSBTAG00000020205
Not yet available
Pathways
NETPATH
REACTOME
REACT_242871
G alpha (s) signalling events pathway
REACT_223625
GPCR downstream signaling pathway
REACT_254215
Signaling by GPCR pathway
REACT_188257
Signal Transduction pathway
KEGG
mmu00230
Purine metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_19327
G alpha (s) signalling events pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
KEGG
hsa00230
Purine metabolism pathway
INOH
INOH website
Purine nucleotides nucleosides metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.100167
RefSeq NM_001170669 NM_172263 XM_006517589 XM_006517595
OMIM
CCDS CCDS49331 CCDS49332
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca