InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pcsk4

Summary

InnateDB Protein

IDBP-173666.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pcsk4

Protein Name

proprotein convertase subtilisin/kexin type 4

Synonyms

AI647044; L21221; NEC 3; NEC3; PC4; SPC5;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000020340

InnateDB Gene

IDBG-173664 (Pcsk4)

Protein Structure

UniProt Annotation

Function

Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed abundantly in the testis. {ECO:0000269PubMed:1372895}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004252	serine-type endopeptidase activity

Biological Process

GO:0006508	proteolysis
GO:0007339	binding of sperm to zona pellucida
GO:0007340	acrosome reaction
GO:0009566	fertilization
GO:0048240	sperm capacitation

Cellular Component

GO:0002080	acrosomal membrane
GO:0005788	endoplasmic reticulum lumen

Protein Structure and Domains

PDB ID

MGI:97514

InterPro

IPR000209 Peptidase S8/S53 domain
IPR002884 Proprotein convertase, P
IPR008979 Galactose-binding domain-like
IPR009020 Proteinase inhibitor, propeptide
IPR015500 Peptidase S8, subtilisin-related

PFAM

PF00082
PF01483

PRINTS

PR00723

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P29121