Homo sapiens Protein: DPP8
Summary
InnateDB Protein IDBP-17367.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DPP8
Protein Name dipeptidyl-peptidase 8
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000339208
InnateDB Gene IDBG-17359 (DPP8)
Protein Structure
UniProt Annotation
Function Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2. May play a role in T-cell activation and immune function. {ECO:0000269PubMed:11012666}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:11012666, ECO:0000269PubMed:12534281, ECO:0000269PubMed:12662155}.
Disease Associations
Tissue Specificity Ubiquitously expressed, with highest levels in testis, placenta, prostate, muscle and brain. {ECO:0000269PubMed:11012666, ECO:0000269PubMed:12662155}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated
Total 17 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008236 serine-type peptidase activity
GO:0008239 dipeptidyl-peptidase activity
GO:0016787 hydrolase activity
Biological Process
GO:0006508 proteolysis
GO:0006955 immune response
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR000383 Xaa-Pro dipeptidyl-peptidase-like domain
IPR001375 Peptidase S9, prolyl oligopeptidase, catalytic domain
IPR002469 Peptidase S9B, dipeptidylpeptidase IV N-terminal
IPR029058 Alpha/Beta hydrolase fold
PFAM PF02129
PF00326
PF00930
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6V1X1
PhosphoSite PhosphoSite-Q6V1X1
TrEMBL H0YN53
UniProt Splice Variant
Entrez Gene 54878
UniGene Hs.623476
RefSeq NP_932064
HUGO HGNC:16490
OMIM 606819
CCDS CCDS10207
HPRD 07076
IMGT
EMBL AC011846 AC105129 AF173382 AF175225 AF176779 AF221634 AF221635 AF221636 AF221637 AK000290 AK027826 AY172659 AY354202 BC030688 BC040203 CH471082
GenPept AAG29766 AAG29767 AAG29768 AAG29769 AAH30688 AAO17261 AAQ13623 AAQ13650 AAQ13657 AAQ63887 BAA91059 BAB55395 EAW77731 EAW77733