Mus musculus Protein: Xrcc3 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Protein | IDBP-173750.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | Xrcc3 | ||||||||||||||||||
Protein Name | X-ray repair complementing defective repair in Chinese hamster cells 3 | ||||||||||||||||||
Synonyms | 4432412E01Rik; AI182522; AW537713; | ||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||
Ensembl Protein | ENSMUSP00000021715 | ||||||||||||||||||
InnateDB Gene | IDBG-173748 (Xrcc3) | ||||||||||||||||||
Protein Structure | |||||||||||||||||||
UniProt Annotation | |||||||||||||||||||
Function | Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD21 paralog protein complex CX3 which acts in the BRCA1-BRCA2- dependent HR pathway. Upon DNA damage, CX3 acts downstream of RAD51 recruitment; the complex binds predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junctions of replication forks. Involved in HJ resolution and thus in processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex and seems to involve GEN1 during mitotic cell cycle progression. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C (By similarity). {ECO:0000250}. | ||||||||||||||||||
Subcellular Localization | Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Mitochondrion matrix {ECO:0000250}. Note=Accumulates in discrete nuclear foci prior to DNA damage, and these foci persist throughout the time course of DNA repair. {ECO:0000250}. | ||||||||||||||||||
Disease Associations | |||||||||||||||||||
Tissue Specificity | |||||||||||||||||||
Comments | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||
PDB ID | MGI:1921585 | ||||||||||||||||||
InterPro |
IPR013632
DNA recombination and repair protein Rad51, C-terminal IPR016467 DNA recombination and repair protein, RecA-like IPR020588 DNA recombination and repair protein RecA-like, ATP-binding domain IPR027417 P-loop containing nucleoside triphosphate hydrolase |
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PFAM |
PF08423
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PRINTS | |||||||||||||||||||
PIRSF |
PIRSF005856
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SMART | |||||||||||||||||||
TIGRFAMs | |||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||
Modification | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | Q9CXE6 | ||||||||||||||||||
PhosphoSite | PhosphoSite-Q9CXE6 | ||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 74335 | ||||||||||||||||||
UniGene | Mm.19082 | ||||||||||||||||||
RefSeq | NP_083151 | ||||||||||||||||||
MGI ID | |||||||||||||||||||
MGI Symbol | Xrcc3 | ||||||||||||||||||
OMIM | |||||||||||||||||||
CCDS | CCDS26187 | ||||||||||||||||||
HPRD | |||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AK014491 | ||||||||||||||||||
GenPept | BAB29391 | ||||||||||||||||||