InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nrk

Summary

InnateDB Protein

IDBP-173795.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nrk

Protein Name

Nik related kinase

Synonyms

AA407323; AA409510; AI225895; AV168563; AW538185; Nesk;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000063397

InnateDB Gene

IDBG-173793 (Nrk)

Protein Structure

UniProt Annotation

Function

May phosphorylate cofilin-1 and induce actin polymerization through this process, during the late stages of embryogenesis. Involved in the TNF-alpha-induced signaling pathway. {ECO:0000269PubMed:10801798, ECO:0000269PubMed:12837278}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004702	receptor signaling protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005083	small GTPase regulator activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0007256	activation of JNKK activity
GO:0007567	parturition
GO:0008285	negative regulation of cell proliferation
GO:0060721	regulation of spongiotrophoblast cell proliferation

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

MGI:1351326

InterPro

IPR000719 Protein kinase domain
IPR001180 Citron-like
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF00780
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00036
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt