InnateDB Protein
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IDBP-17382.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MOAP1
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Protein Name
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modulator of apoptosis 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000298894
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InnateDB Gene
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IDBG-17380 (MOAP1)
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Protein Structure
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Function |
Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. {ECO:0000269PubMed:15949439}.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
Widely expressed, with high levels in heart and brain. {ECO:0000269PubMed:19366867}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
25
[view]
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Protein-Protein |
24
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0001844
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protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
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GO:0008625
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extrinsic apoptotic signaling pathway via death domain receptors
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GO:0008630
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intrinsic apoptotic signaling pathway in response to DNA damage
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GO:0043065
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positive regulation of apoptotic process
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GO:0090200
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positive regulation of release of cytochrome c from mitochondria
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GO:0097190
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apoptotic signaling pathway
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GO:0097192
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extrinsic apoptotic signaling pathway in absence of ligand
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q96BY2
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PhosphoSite |
PhosphoSite-Q96BY2
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
64112
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UniGene |
Hs.24719
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RefSeq |
NP_071434
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HUGO |
HGNC:16658
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OMIM |
609485
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CCDS |
CCDS9908
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HPRD |
17580
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IMGT |
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EMBL |
AF305550
AK024029
AK315522
BC015044
CH471061
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GenPept |
AAG31786
AAH15044
BAB14788
BAG37903
EAW81516
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