InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc4a10

Summary

InnateDB Protein

IDBP-173887.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc4a10

Protein Name

solute carrier family 4, sodium bicarbonate cotransporter-like, member 10

Synonyms

mKIAA4136; NCBE;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099796

InnateDB Gene

IDBG-173885 (Slc4a10)

Protein Structure

UniProt Annotation

Function

Electrogenic sodium/bicarbonate cotransporter in exchange for intracellular chloride. Plays an important role in regulating intracellular pH. {ECO:0000269PubMed:10993873}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:14592810}; Multi-pass membrane protein {ECO:0000269PubMed:14592810}. Note=Localizes to the basolateral membrane. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in pancreatic islets and in the brain, in the epithelial cells of the choroid plexus. {ECO:0000269PubMed:10993873, ECO:0000269PubMed:14592810}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005452	inorganic anion exchanger activity
GO:0008509	anion transmembrane transporter activity
GO:0015293	symporter activity
GO:0015301	anion:anion antiporter activity

Biological Process

GO:0006486	protein glycosylation
GO:0006810	transport
GO:0006814	sodium ion transport
GO:0006820	anion transport
GO:0006885	regulation of pH
GO:0055085	transmembrane transport

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane

Protein Structure and Domains

PDB ID

MGI:2150150

InterPro

IPR003020 Bicarbonate transporter, eukaryotic
IPR003024 Sodium bicarbonate cotransporter
IPR011531 Bicarbonate transporter, C-terminal
IPR013769 Band 3 cytoplasmic domain
IPR016152 Phosphotransferase/anion transporter

PFAM

PF00955
PF07565

PRINTS

PR01231
PR01232

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q5DTL9