Version 5.4
Mus musculus Gene: Slc4a10
Summary
InnateDB Gene IDBG-173885.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Slc4a10
Gene Name solute carrier family 4, sodium bicarbonate cotransporter-like, member 10
Synonyms mKIAA4136; NCBE
Species Mus musculus
Ensembl Gene ENSMUSG00000026904
Encoded Proteins
IDBP-173887
solute carrier family 4, sodium bicarbonate cotransporter-like, member 10
IDBP-173889
solute carrier family 4, sodium bicarbonate cotransporter-like, member 10
IDBP-255922
solute carrier family 4, sodium bicarbonate cotransporter-like, member 10
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000144290:
This gene belongs to a small family of sodium-coupled bicarbonate transporters (NCBTs) that regulate the intracellular pH of neurons, the secretion of bicarbonate ions across the choroid plexus, and the pH of the brain extracellular fluid. The protein encoded by this gene was initially identified as a sodium-driven chloride bicarbonate exchanger (NCBE) though there is now evidence that its sodium/bicarbonate cotransport activity is independent of any chloride ion countertransport under physiological conditions. This gene is now classified as a member A10 of the SLC4 family of transmembrane solute carriers. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:62046462-62326730
Strand Forward strand
Band C1.3
Transcripts
ENSMUST00000102735 ENSMUSP00000099796
ENSMUST00000054484 ENSMUSP00000061411
ENSMUST00000112480 ENSMUSP00000108099
ENSMUST00000155219
ENSMUST00000149527
ENSMUST00000147917
ENSMUST00000156534
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005452 inorganic anion exchanger activity
GO:0008509 anion transmembrane transporter activity
GO:0015293 symporter activity
GO:0015301 anion:anion antiporter activity
Biological Process
GO:0006486 protein glycosylation
GO:0006810 transport
GO:0006814 sodium ion transport
GO:0006820 anion transport
GO:0006885 regulation of pH
GO:0055085 transmembrane transport
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000144290
View Gene Order
ENSBTAG00000015317
Not yet available
Pathways
NETPATH
REACTOME
REACT_247550
SLC-mediated transmembrane transport pathway
REACT_251788
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
REACT_229600
Bicarbonate transporters pathway
REACT_253400
Transmembrane transport of small molecules pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_19298
Bicarbonate transporters pathway
REACT_19397
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_19118
SLC-mediated transmembrane transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.314497 Mm.487091
RefSeq NM_001242378 NM_001242379 NM_001242380 NM_001242381 NM_001242382 NM_001242383 NM_033552 XM_006500449 XM_006500450 XM_006500451
OMIM
CCDS CCDS16064 CCDS57172 CCDS57173
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca