InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: F2rl2

Summary

InnateDB Protein

IDBP-174180.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

F2rl2

Protein Name

coagulation factor II (thrombin) receptor-like 2

Synonyms

F730031A08; PAR3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022182

InnateDB Gene

IDBG-174178 (F2rl2)

Protein Structure

UniProt Annotation

Function

High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0015057	thrombin receptor activity

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007596	blood coagulation
GO:0070493	thrombin receptor signaling pathway

Cellular Component

GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane

Protein Structure and Domains

PDB ID

MGI:1298208

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR003912 Protease-activated receptor
IPR003943 Protease-activated receptor 3
IPR017452 GPCR, rhodopsin-like, 7TM

PFAM

PF00001

PRINTS

PR00237
PR01428
PR01429

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O08675