Version 5.4
Mus musculus Protein: Igfbp7
Summary
InnateDB Protein IDBP-174287.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Igfbp7
Protein Name insulin-like growth factor binding protein 7
Synonyms AGM; Fstl2; Mac25;
Species Mus musculus
Ensembl Protein ENSMUSP00000045057
InnateDB Gene IDBG-174285 (Igfbp7)
Protein Structure
UniProt Annotation
Function Binds IGF-I and IGF-II with a relatively low affinity Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion (By similarity). {ECO:0000250}.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Expressed at high levels in lung, kidney, small intestine, testis and uterus and at moderate levels in liver. {ECO:0000269PubMed:10623583}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005520 insulin-like growth factor binding
Biological Process
GO:0001558 regulation of cell growth
GO:0007155 cell adhesion
GO:0048839 inner ear development
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID MGI:1352480
InterPro IPR000867 Insulin-like growth factor-binding protein, IGFBP
IPR002350 Kazal domain
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR011390 Insulin-like growth factor binding protein-related protein (IGFBP-rP), MAC25
IPR013098 Immunoglobulin I-set
PFAM PF00219
PF00050
PF07648
PF07679
PRINTS
PIRSF PIRSF018239
SMART SM00121
SM00280
SM00408
SM00409
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q61581
PhosphoSite PhosphoSite-
TrEMBL F8WH23
UniProt Splice Variant
Entrez Gene 29817
UniGene Mm.233470
RefSeq NP_032074
MGI ID
MGI Symbol Igfbp7
OMIM
CCDS CCDS51529
HPRD
IMGT
EMBL AB012886 AB042198 AC122396 AC141469 L75822
GenPept AAC37696 BAA33569 BAB17228

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca