InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Igfbp7

Summary

InnateDB Gene

IDBG-174285.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Igfbp7

Gene Name

insulin-like growth factor binding protein 7

Synonyms

AGM; Fstl2; Mac25

Species

Mus musculus

Ensembl Gene

ENSMUSG00000036256

Encoded Proteins

IDBP-174287

insulin-like growth factor binding protein 7

IDBP-623513

insulin-like growth factor binding protein 7

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163453:
This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and one variant has been associated with retinal arterial macroaneurysm (PMID:21835307). [provided by RefSeq, Dec 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:77349240-77408045

Strand

Reverse strand

Band

C3.3

Transcripts

ENSMUST00000046746	ENSMUSP00000045057
ENSMUST00000163898	ENSMUSP00000128318

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005520	insulin-like growth factor binding

Biological Process

GO:0001558	regulation of cell growth
GO:0007155	cell adhesion
GO:0007566	embryo implantation
GO:0009408	response to heat
GO:0014070	response to organic cyclic compound
GO:0032526	response to retinoic acid
GO:0032870	cellular response to hormone stimulus
GO:0048839	inner ear development
GO:0050810	regulation of steroid biosynthetic process
GO:0051414	response to cortisol

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000163453

View Gene Order

ENSBTAG00000019368

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_120956

Cellular responses to stress pathway

REACT_169274

Cellular Senescence pathway

REACT_169168

Senescence-Associated Secretory Phenotype (SASP) pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

E9Q5D9

UniProt Splice Variant

Entrez Gene

29817

UniGene

Mm.233470

RefSeq

NM_001159518 NM_008048

OMIM

CCDS

CCDS51530 CCDS51529

HPRD

IMGT

MGI ID

MGI:1352480

MGI Symbol

Igfbp7

EMBL

AC122396 AC141469

GenPept

RNA Seq Atlas

29817