InnateDB Protein
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IDBP-174312.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Eps15
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Protein Name
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epidermal growth factor receptor pathway substrate 15
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Synonyms
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2410112D09Rik;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000030281
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InnateDB Gene
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IDBG-174308 (Eps15)
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Protein Structure
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Function |
Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta- 1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.
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Subcellular Localization |
Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, clathrin-coated pit. Note=Recruited to the plasma membrane upon EGFR activation and localizes to coated pits.Isoform 2: Early endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Colocalizes with HGS on bilayered clathrin coats on endosomes. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 104 interaction(s) predicted by orthology.
Experimentally validated |
Total |
34
[view]
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Protein-Protein |
34
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
104 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:104583
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InterPro |
IPR003903
Ubiquitin interacting motif
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PFAM |
PF02809
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PRINTS |
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PIRSF |
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SMART |
SM00726
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TIGRFAMs |
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Modification |
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SwissProt |
P42567
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PhosphoSite |
PhosphoSite-P42567
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
13858
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UniGene |
Mm.471235
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RefSeq |
NP_001153436
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MGI ID |
1QJT
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MGI Symbol |
Eps15
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OMIM |
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CCDS |
CCDS51259
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HPRD |
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IMGT |
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EMBL |
AK083176
AL669905
L21768
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GenPept |
AAA02912
BAC38796
CAM13653
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