InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Eps15

Summary

InnateDB Gene

IDBG-174308.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Eps15

Gene Name

epidermal growth factor receptor pathway substrate 15

Synonyms

2410112D09Rik

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028552

Encoded Proteins

IDBP-174310

epidermal growth factor receptor pathway substrate 15

IDBP-174312

epidermal growth factor receptor pathway substrate 15

IDBP-538657

epidermal growth factor receptor pathway substrate 15

IDBP-717942

IDBP-718544

IDBP-718811

IDBP-717475

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000085832:
This gene encodes a protein that is part of the EGFR pathway. The protein is present at clatherin-coated pits and is involved in receptor-mediated endocytosis of EGF. Notably, this gene is rearranged with the HRX/ALL/MLL gene in acute myelogeneous leukemias. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:109280268-109387817

Strand

Forward strand

Band

Transcripts

ENSMUST00000102729	ENSMUSP00000099790
ENSMUST00000030281	ENSMUSP00000030281
ENSMUST00000150755
ENSMUST00000141751
ENSMUST00000132165	ENSMUSP00000118949
ENSMUST00000126015
ENSMUST00000177140
ENSMUST00000175776	ENSMUSP00000135270
ENSMUST00000177192	ENSMUSP00000135755
ENSMUST00000176251	ENSMUSP00000135034
ENSMUST00000177089	ENSMUSP00000134922

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 104 interaction(s) predicted by orthology.

Experimentally validated
Total	34 [view]
Protein-Protein	34 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	104 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0017124	SH3 domain binding
GO:0031593	polyubiquitin binding
GO:0042802	identical protein binding

Biological Process

GO:0006895	Golgi to endosome transport
GO:0006897	endocytosis
GO:0015031	protein transport
GO:0048268	clathrin coat assembly

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005905	coated pit
GO:0016020	membrane
GO:0030122	AP-2 adaptor complex
GO:0030132	clathrin coat of coated pit
GO:0030136	clathrin-coated vesicle
GO:0031901	early endosome membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0060170	ciliary membrane