InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Shank3

Summary

InnateDB Protein

IDBP-174489.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Shank3

Protein Name

SH3/ankyrin domain gene 3

Synonyms

AI841104; Shank3b; SHANK3c-3; SHANK3c-4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000064477

InnateDB Gene

IDBG-174485 (Shank3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0008270	zinc ion binding
GO:0017124	SH3 domain binding
GO:0030160	GKAP/Homer scaffold activity
GO:0035255	ionotropic glutamate receptor binding
GO:0042802	identical protein binding
GO:0043621	protein self-association
GO:0097110	scaffold protein binding

Biological Process

GO:0000165	MAPK cascade
GO:0001838	embryonic epithelial tube formation
GO:0007416	synapse assembly
GO:0007612	learning
GO:0007613	memory
GO:0021773	striatal medium spiny neuron differentiation
GO:0032232	negative regulation of actin filament bundle assembly
GO:0035176	social behavior
GO:0035641	locomotory exploration behavior
GO:0045794	negative regulation of cell volume
GO:0048170	positive regulation of long-term neuronal synaptic plasticity
GO:0048854	brain morphogenesis
GO:0050885	neuromuscular process controlling balance
GO:0051259	protein oligomerization
GO:0051835	positive regulation of synapse structural plasticity
GO:0051968	positive regulation of synaptic transmission, glutamatergic
GO:0060997	dendritic spine morphogenesis
GO:0060999	positive regulation of dendritic spine development
GO:0061001	regulation of dendritic spine morphogenesis
GO:0071625	vocalization behavior
GO:0097107	postsynaptic density assembly
GO:0097113	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering
GO:0097114	N-methyl-D-aspartate receptor clustering
GO:0097117	guanylate kinase-associated protein clustering
GO:1900271	regulation of long-term synaptic potentiation
GO:1900451	positive regulation of glutamate receptor signaling pathway
GO:1900452	regulation of long term synaptic depression
GO:2000463	positive regulation of excitatory postsynaptic membrane potential
GO:2000821	regulation of grooming behavior
GO:2000822	regulation of behavioral fear response
GO:2000969	positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0030054	cell junction
GO:0043005	neuron projection
GO:0043197	dendritic spine
GO:0044309	neuron spine
GO:0045211	postsynaptic membrane
GO:0060076	excitatory synapse
GO:0060170	ciliary membrane
GO:0097481	neuronal postsynaptic density