InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Adssl1

Summary

InnateDB Protein

IDBP-174519.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Adssl1

Protein Name

adenylosuccinate synthetase like 1

Synonyms

Adss; Adss1; AI528595;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021726

InnateDB Gene

IDBG-174517 (Adssl1)

Protein Structure

UniProt Annotation

Function

Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. {ECO:0000269PubMed:12482871}.

Subcellular Localization

Cytoplasm. Membrane; Peripheral membrane protein. Note=Partially associated with particulate fractions.

Disease Associations

Tissue Specificity

High levels in muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0003924	GTPase activity
GO:0004019	adenylosuccinate synthase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0042803	protein homodimerization activity
GO:0051015	actin filament binding

Biological Process

GO:0006163	purine nucleotide metabolic process
GO:0006164	purine nucleotide biosynthetic process
GO:0006184	GTP catabolic process
GO:0006531	aspartate metabolic process
GO:0006541	glutamine metabolic process
GO:0014850	response to muscle activity
GO:0035690	cellular response to drug
GO:0042594	response to starvation
GO:0044208	'de novo' AMP biosynthetic process
GO:0046040	IMP metabolic process
GO:0071257	cellular response to electrical stimulus