InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dner

Summary

InnateDB Protein

IDBP-174642.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dner

Protein Name

delta/notch-like EGF-related receptor

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000042927

InnateDB Gene

IDBG-174640 (Dner)

Protein Structure

UniProt Annotation

Function

Mediates neuron-glia interaction during astrocytogenesis. May promote differentiation of Bergmann glia during cerebellar development by activating DELTEX-dependent NOTCH1 signaling. {ECO:0000269PubMed:15965470, ECO:0000269PubMed:16298139}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:11950833, ECO:0000269PubMed:11997712}; Single-pass type I membrane protein {ECO:0000269PubMed:11950833, ECO:0000269PubMed:11997712}. Note=Present on the membrane of dendrites and cell bodies but excluded from axonal membrane. Also found in early endosomes in the somatodendritic region.

Disease Associations

Tissue Specificity

Specifically expressed in brain neurons (at protein level). {ECO:0000269PubMed:11950833, ECO:0000269PubMed:11997712}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005112	Notch binding
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0007219	Notch signaling pathway
GO:0007220	Notch receptor processing
GO:0007417	central nervous system development
GO:0010001	glial cell differentiation
GO:0048741	skeletal muscle fiber development