InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cdkn2c

Summary

InnateDB Protein

IDBP-174650.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cdkn2c

Protein Name

cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)

Synonyms

C77269; INK4c; p18; p18-INK4c; p18-INK6; p18INK4c;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000070313

InnateDB Gene

IDBG-174648 (Cdkn2c)

Protein Structure

UniProt Annotation

Function

Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005515	protein binding
GO:0019901	protein kinase binding

Biological Process

GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000082	G1/S transition of mitotic cell cycle
GO:0007050	cell cycle arrest
GO:0008285	negative regulation of cell proliferation
GO:0030308	negative regulation of cell growth
GO:0048709	oligodendrocyte differentiation
GO:0071901	negative regulation of protein serine/threonine kinase activity