InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cdkn2c

Summary

InnateDB Gene

IDBG-174648.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cdkn2c

Gene Name

cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)

Synonyms

C77269; INK4c; p18; p18-INK4c; p18-INK6; p18INK4c

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028551

Encoded Proteins

IDBP-174650

cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)

IDBP-174652

cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase (cdk) inhibitors, and contains five ankyrin repeats. This protein interacts with both Cdk4 and Cdk6 to inhibit their kinase activities, and prevent their interactions with D-type cyclins, thereby negatively regulating cell division. This gene is differentially expressed in a variety of tissues, and is cell cycle regulated. Deletion of this gene can lead to tumor growth. Maximal expression is observed at the G2/M phase. Alternative splicing and promoter usage results in multiple transript variants. [provided by RefSeq, Aug 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:109660876-109667189

Strand

Reverse strand

Band

Transcripts

ENSMUST00000063531	ENSMUSP00000070313
ENSMUST00000097921	ENSMUSP00000095534

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005515	protein binding
GO:0019901	protein kinase binding

Biological Process

GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000082	G1/S transition of mitotic cell cycle
GO:0007050	cell cycle arrest
GO:0008285	negative regulation of cell proliferation
GO:0030308	negative regulation of cell growth
GO:0042326	negative regulation of phosphorylation
GO:0048709	oligodendrocyte differentiation
GO:0071901	negative regulation of protein serine/threonine kinase activity