Version 5.4
Mus musculus Protein: Acr
Summary
InnateDB Protein IDBP-174670.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Acr
Protein Name acrosin prepropeptide
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000023295
InnateDB Gene IDBG-174668 (Acr)
Protein Structure
UniProt Annotation
Function Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004040 amidase activity
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0005537 mannose binding
GO:0008144 drug binding
GO:0008233 peptidase activity
GO:0042806 fucose binding
Biological Process
GO:0006508 proteolysis
GO:0007190 activation of adenylate cyclase activity
GO:0007338 single fertilization
GO:0007339 binding of sperm to zona pellucida
GO:0007340 acrosome reaction
GO:0007341 penetration of zona pellucida
GO:0048545 response to steroid hormone
Cellular Component
GO:0001669 acrosomal vesicle
GO:0005634 nucleus
GO:0005798 Golgi-associated vesicle
GO:0043159 acrosomal matrix
GO:0043234 protein complex
Protein Structure and Domains
PDB ID MGI:87884
InterPro IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR009003 Trypsin-like cysteine/serine peptidase domain
IPR012267 Peptidase S1A, acrosin
PFAM PF00089
PRINTS PR00722
PIRSF PIRSF001141
SMART SM00020
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P23578
PhosphoSite PhosphoSite-
TrEMBL Q3ZB06
UniProt Splice Variant
Entrez Gene 11434
UniGene Mm.57
RefSeq NP_038483
MGI ID
MGI Symbol Acr
OMIM
CCDS CCDS27755
HPRD
IMGT
EMBL BC103577 BC103578 BC103579 D00754 M85170 M96426 M96427 M96428 M96430 S64500 S66243 S66245 X52466
GenPept AAA37163 AAA40124 AAB20293 AAI03578 AAI03579 AAI03580 BAA00651 CAA36704

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca