Version 5.4
| Mus musculus Protein: Adam2 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-174829.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Adam2 | ||||||||
| Protein Name | a disintegrin and metallopeptidase domain 2 | ||||||||
| Synonyms | AI323749; Ftnb; Ph30-beta; | ||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000022618 | ||||||||
| InnateDB Gene | IDBG-174827 (Adam2) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein (By similarity). {ECO:0000250}. | ||||||||
| Subcellular Localization | Membrane; Single-pass type I membrane protein. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | Expressed specifically in testis. | ||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | MGI:1340894 | ||||||||
| InterPro |
IPR000742
Epidermal growth factor-like domain IPR001590 Peptidase M12B, ADAM/reprolysin IPR001762 Blood coagulation inhibitor, Disintegrin IPR002870 Peptidase M12B, propeptide IPR006586 ADAM, cysteine-rich |
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| PFAM |
PF00008
PF01421 PF00200 PF01562 PF08516 |
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| PRINTS |
PR00289
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| PIRSF | |||||||||
| SMART |
SM00181
SM00050 SM00608 |
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q60718 | ||||||||
| PhosphoSite | PhosphoSite-Q60718 | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 11495 | ||||||||
| UniGene | Mm.422850 | ||||||||
| RefSeq | NP_033748 | ||||||||
| MGI ID | |||||||||
| MGI Symbol | Adam2 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS36959 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AK016550 U16242 U22057 U38806 | ||||||||
| GenPept | AAA74921 AAA90980 AAD04207 BAB30298 | ||||||||